Bone Abstracts

Periostin (osteoblast-specific factor OSF-2) is a glycoprotein that in humans is encoded by the POSTN gene. It is a component of the extracellular matrix and is thought to be involved in osteoblast recruitment, attachment and spreading.The N-terminus part of periostin is conserved, while the C-terminal region gives rise to different splice isoforms upon alternative splicing. The isoforms have a molecular weight range from 83 to 93 kDa.<p class="abste...

Objectives: Fibroblast growth factor 23 (FGF23) is a bone-derived phosphaturic hormone. The main target organ is the kidney, where FGF23 suppresses renal phosphate reabsorption and vitamin D synthesis. It also stimulates calcium reabsorption in the kidney. FGF23 secretion is stimulated by 1,25(OH)2D and by increased extracellular phosphate concentration, thus forming a feedback loop between kidney and bone. The bioactive intact FGF23 contains 251 amino acids and is glycosylate...